• Nannan Sun, Clement Brault, Antenor Rodrigues, Matthew Ko, Fernando Vieira, Vorakamol Phoophiboon, Michel Slama, Lu Chen, and Laurent Brochard.
• Keenan Centre for Biomedical Research, Li Ka Shing Knowledge Institute, Unity Health Toronto, Toronto, ON, Canada.
• Crit Care. 2025 Jan 16; 29 (1): 2828.

BackgroundIn patients with acute hypoxemic respiratory failure (AHRF) under mechanical ventilation, the change in pressure slope during a low-flow insufflation indicates a global airway opening pressure (AOP) needed to reopen closed airways and may be used for titration of positive end-expiratory pressure.ObjectivesTo understand 1) if airways open homogeneously inside the lungs or significant regional AOP variations exist; 2) whether the pattern of the pressure slope change during low-flow insufflation can indicate the presence of regional AOP variations.MethodsUsing electrical impedance tomography, we recorded low-flow insufflation maneuvers (< 10 L/min) starting from end-expiratory positive pressure 0-5 cmH2O. We measured global (AOPglobal) and regional AOPs from pressure-impedance curves in the four different lung quadrants, and compared AOPglobal with the highest quadrantal AOP (AOPhighest). We categorized the slope change of the low-flow inflation pressure-time curve into three patterns: no change, progressive change, abrupt change.ResultsAmong the 36 patients analyzed, 9 (25%) had AOPglobal ≥ 5 cmH2O whereas 19 (53%) exhibited regional AOPhighest ≥ 5 cmH2O. AOPglobal was on average similar to AOP of the upper right quadrant (P = 0.182) but was lower than AOPs of the other three quadrants (P < 0.01 of each). AOPglobal was significantly lower than AOPhighest: 3.0 [2.0-4.3] vs. 5.0 [2.8-8.3] cmH2O, P < 0.001. AOP was higher in the dependent than the non-dependent ventilated lung (4.0 [2.0-6.3] vs. 3.0 [2.0-5.0] cmH2O, P < 0.001). Seventeen (47%) patients exhibited a 'progressive change' pattern in the pressure-time curve. These patients had a larger difference between AOPhighest and AOPglobal (3.0 [2.0-4.0] cmH2O with a maximum of 8 cmH2O) compared to the other two patterns: 1.0 [0-1.0] cmH2O in 'no change' , P < 0.001 and 1.0 [0-2.0] cmH2O in 'abrupt change' , P = 0.003.ConclusionAOPglobal mostly reflects the lowest opening pressure in the lung and frequently underestimates the highest regional AOP in mechanically ventilated patients with AHRF. A progressive slope change during the low-flow pressure-time curve indicates the presence of several and higher regional AOPs.Trial RegistrationClinicaltrials.gov, NCT05825534 (registered, April 24th, 2023), retrospectively registered.© 2025. The Author(s).

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