• J Am Board Fam Med · Jan 2025

    Doxycycline Postexposure Prophylaxis for Sexually Transmitted Infection Prevention.

    • Elizabeth Close, Alexander Jones, and William Noggle.
    • From the University of Tennessee College of Medicine Family Medicine Residency, Chattanooga, TN. betsyclose@gmail.com.
    • J Am Board Fam Med. 2025 Jan 17.

    AbstractConsider prescribing doxycycline as prophylaxis for bacterial sexually transmitted infections (STIs) in certain clinical scenarios. New data suggests that a one-time dose of 200 mg doxycycline taken within 72 hours of an unprotected sexual encounter may reduce transmission of syphilis, gonorrhea and chlamydia by a combined two thirds in a high-risk population.© Copyright 2025 by Family Physicians Inquiries Network, Inc.

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