• Ailyn Morales-Rentería, Amina Ruiz-Santos, Luis M Amezcua-Castillo, Jazmín A Guerra-López, Kietseé A Díaz-Domínguez, José L Sánchez-Gloria, Héctor González-Pacheco, and Luis M Amezcua-Guerra.
• School of Medicine, Universidad Autónoma Metropolitana (UAM)-Xochimilco, Mexico City, Mexico.
• Rev Invest Clin. 2025 Jan 14.

BackgroundMiR-155 plays a role in inflammatory pathways and cardiovascular diseases, though its relationship with inflammation, atherosclerosis, and outcomes in ST-elevation myocardial infarction (STEMI) is not well established.ObjectiveTo investigate associations between miR-155 levels, inflammation, atherosclerotic burden, and major adverse cardiovascular events (MACE) in STEMI patients.MethodsSixty-nine STEMI patients and 16 healthy controls were recruited from a specialized university-affiliated cardiovascular center. MiR-155 expression and serum interleukin (IL)-1β, IL-6, and tumor necrosis factor levels were measured. Patients were grouped into tertiles based on miR-155 expression. Clinical data, atherosclerotic burden (through cardiac catheterization), and in-hospital MACE were recorded.ResultsMiR-155 levels were significantly lower in STEMI patients compared to controls (median 54.2, vs. 152.8 arbitrary units; p = 0.003). Higher miR-155 tertiles were associated with a greater prevalence of three-vessel occlusion (34% vs. 13% vs. 4%; p = 0.007) and increased incidence of pulmonary edema (13% vs. 0% vs. 0%; p = 0.030). No significant correlation was found between miR-155 and inflammatory or myocardial markers.ConclusionDysregulated miR-155 expression in STEMI patients may influence disease severity and MACE risk, independent of inflammation or myocardial damage markers.

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