• Tommi Bergman, Maija-Liisa Kalliomäki, Mika Särkelä, and Jarkko Harju.
• Tampere University Hospital, Tampere, Finland. tommi.bergman@pirha.fi.
• J Clin Monit Comput. 2025 Jan 20.

AbstractThe measurement of nociception and the optimisation of intraoperative antinociceptive medication could potentially improve the conduct of anaesthesia, especially in the older population. The Surgical Pleth Index (SPI) is one of the monitoring methods presently used for the detection of nociceptive stimulus. Eighty patients aged 50 years and older who were scheduled to undergo major abdominal surgery were randomised and divided into a study group and a control group. In the study group, the SPI was used to guide the administration of remifentanil during surgery. In the control group, the SPI value was concealed, and remifentanil administration was based on the clinical evaluation of the attending anaesthesiologist. The primary endpoint of this study was intraoperative remifentanil consumption. In addition, we compared the durations of intraoperative hypotension and hypertension. No difference in intraoperative remifentanil consumption (4.5 µg kg- 1h- 1 vs. 5.6 µg kg- 1h- 1, p = 0.14) was found. Furthermore, there was no difference in the proportion of hypotensive time (mean arterial pressure, MAP < 65) (3.7% vs. 1.6%, p = 0.40). However, in the subgroup of patients who underwent operation with invasive blood pressure monitoring, there was less severe hypotension (MAP < 55) (0.3% vs. 0.0%, p = 0.02) and intermediate hypotension (MAP < 65) (10.2% vs. 2.6%, p = 0.07) in the treatment group, even though remifentanil consumption was higher (3.5 µg kg- 1h- 1 vs. 5.1 µg kg- 1h- 1p = 0.03). The use of SPI guidance for the administration of remifentanil during surgery did not help to reduce the remifentanil consumption. However, the results from invasively monitored study group suggest more timely administered opioid when SPI was used.© 2025. The Author(s).

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