• Fan Li, Xueqiang Jiang, Yanwei Liu, Wan Wang, and Congyu Zhang.
• Department of General Practice, Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan, China.
• Medicine (Baltimore). 2025 Jan 17; 104 (3): e40839e40839.

RationaleNovel coronavirus pneumonia is spreading in many countries and regions. Coronavirus disease (COVID-19) is characterized by rapid onset, high infectivity, rapid progression, and variably effective treatment.Patient ConcernsOne 63-year-old woman presented to the fever clinic of our hospital on February 10, 2020, due to a fever for 12 days.DiagnosesCOVID-19 complicated with liver abscess.InterventionsA case report of a patient with COVID-19 complicated with liver abscess admitted to our hospital was used to explore the treatment methods for COVID-19 complicated with bacterial liver abscess. The sepsis caused by pulmonary viral infection and liver bacterial infection were correctly distinguished, and the patient was cured and discharged after targeted treatment, abscess, and pleural puncture and drainage.OutcomesThe patient was cured with a normal temperature is >3 days and coronavirus 3 consecutive negative nucleic acid detection.LessonsCOVID-19, elderly critically ill patients may be prone to rapid onset, complex disease, multiple organ damage, prolonged hospital stay, and high mortality. In the treatment of such COVID-19 patients, holistic thinking is required, pathology may not be limited to the lung, but may affect other organs, and treatment guidelines should not be blindly followed. Medication may need to be individualized for patients with COVID-19 complicated with liver abscess.Copyright © 2025 the Author(s). Published by Wolters Kluwer Health, Inc.

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