• Paria Moulavi, Afsane Ahmadi, Seyed Jalil Masoumi, Morteza Zare, Mahdi Honardoust, and Rahil Ranjbar.
• Student Research Committee, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
• Medicine (Baltimore). 2025 Jan 17; 104 (3): e41276e41276.

AbstractA recently introduced metric for assessing metabolic syndrome (MetS) is the triglyceride glucose-body mass index (TyG-BMI). Additionally, the glycemic index (GI) is recognized as a significant measure for evaluating conditions associated with blood glucose. In this context, our research explores the correlation between TyG-BMI and GI in relation to diet quality, anthropometric measurements, and blood pressure among individuals diagnosed with MetS. A cross-sectional descriptive-analytical study was conducted on 431 employees with MetS at Shiraz University of Medical Sciences (SUMS). Anthropometric measurements of height, weight, waist circumference (WC), and hip circumference (HC) were taken according to Persian cohort protocols. BMI, C-index, visceral adiposity index (VAI), body adiposity index (BAI), body shape index (ABSI), abdominal volume index (AVI), potential renal acid load (PRAL), TyG-BMI and GI were calculated. A physician measured blood pressure, while the dietary inflammatory index was determined using guidelines. Biochemical parameters were analyzed using standard laboratory techniques. Data analysis was conducted using SPSS software version 21, with a significance threshold set at <.05. A significant correlation was identified between the TyG-BMI index and the PRAL index (β = 0.094, P-value = .026), WC (β = 0.627, P-value < .001), BAI (β = 0.396, P-value < .001), and blood pressure (β = 0.063, P-value = .002). Furthermore, the findings indicated a notable association between the GI and blood pressure (β = 0.610, P-value < .001). The results of this study suggest that managing the PRAL index, body weight, and blood pressure may be associated with an enhanced status of TyG-BMI. Additionally, appropriate GI may be linked to regulated blood pressure. These findings can inform health-related policy decisions for these patients.Copyright © 2025 the Author(s). Published by Wolters Kluwer Health, Inc.

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