• Yuqiong An and Fang Nie.
• Ultrasound Medical Center, Second Hospital of Lanzhou University, Lanzhou, China.
• Medicine (Baltimore). 2025 Jan 17; 104 (3): e41296e41296.

RationaleCardiac papillary fibroelastoma (CPF) is a rare cardiac tumor that can lead to severe and potentially fatal complications such as stroke, myocardial infarction, and sudden cardiac death. The rarity of CPF makes it challenging for clinicians to diagnose and treat, highlighting the importance of timely and accurate diagnosis to prevent catastrophic outcomes. This case report aims to contribute to the clinical understanding of CPF involving the mitral valve (MV), providing insights into diagnosis and treatment strategies.Patient ConcernsWe present a case of CPF attached to the MV in a 69-year-old male patient with a 3-year history of syncope.DiagnosesEchocardiography and computed tomography (CT) imaging confirmed a floating, round-shaped mass on the anterior leaflet MV, with pathological analysis supporting the diagnosis of CPF.InterventionsThe patient underwent the tumor resection and valve repair operation.OutcomesPostoperative recovery was favorable, with no evidence of recurrence or valve dysfunction at 1-year follow-up.LessonsEchocardiography is a valuable diagnostic tool for identifying CPF and guide treatment decisions. This case emphasizes the importance of recognizing this rare valve tumor for timely clinical intervention.Copyright © 2025 the Author(s). Published by Wolters Kluwer Health, Inc.

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