• Linbo Chen, Keke Sun, Yukai Chen, Pingping Hu, and Qi Lin.
• Department of Gastroenterology, The Affiliated People's Hospital of Ningbo University, Ningbo, China.
• Medicine (Baltimore). 2025 Jan 24; 104 (4): e41235e41235.

RationaleGastric antral vascular ectasia (GAVE) is a rare acquired lesion characterized by vascular dilation in the gastric antrum, frequently results in occult or overt gastrointestinal bleeding. Endoscopic intervention remains the cornerstone of therapy. Argon plasma coagulation was previously considered a first treatment option. But recently, endoscopic band ligation (EBL) has emerged as an alternative, increasingly favored for its safety and efficacy. Nonetheless, a consensus on the most effective treatment approach has yet to be established.Patient ConcernsA 74-year-old female was hospitalized for persistent chest tightness and dyspnea for 1 year. Physical examination showed an anemic appearance with normal blood pressure. Upon admission to the hospital, the blood routine examination revealed severe anemia and the fecal occult blood test was persistently positive.DiagnosesThe endoscopic observations and histological evidence led to a diagnosis of GAVE for the patient.InterventionsConsidering the poor response to prior pharmacotherapy, endoscopic intervention was selected for this hospitalization. The initial EBL alone did not yield particularly satisfactory results. Combining EBL with lauromacrogol injection as a subsequent treatment resulted in encouraging outcomes.OutcomesAt the 6-week follow-up, the patient exhibited a negative fecal occult blood test, normalization of hemoglobin level, and endoscopic images demonstrated near complete resolution of vascular ectasias.LessonsThe combination of EBL with lauromacrogol injection has shown a satisfactory short-term outcome, providing a new option for the endoscopic management of GAVE. However, its long-term efficacy still requires further observation.Copyright © 2025 the Author(s). Published by Wolters Kluwer Health, Inc.

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