• Br J Anaesth · Dec 2024

    Editorial

    Management of renin-angiotensin system inhibitors prior to major surgery: insights from the STOP-or-NOT trial.

    • Matthieu Legrand and Etienne Gayat.
    • Department of Anesthesia and Perioperative Care, Division of Critical Care Medicine, University of California, San Francisco, San Francisco, CA, USA; INI-CRCT Network, Nancy, France. Electronic address: matthieu.legrand@ucsf.edu.
    • Br J Anaesth. 2024 Dec 13.

    AbstractStrong recommendations on how to manage renin-angiotensin system inhibitors, including angiotensin-converting enzyme inhibitors and angiotensin receptor blockers, before surgery are lacking because of a lack of evidence, which is mostly limited to data from observational studies. The STOP-or-NOT trial was a large multicentre randomised trial designed to determine whether chronic renin-angiotensin system inhibitors should be continued or discontinued before major noncardiac surgery. As principal investigators of the STOP-or-NOT trial, we discuss the trial's results and how they contribute to the existing literature on management of renin-angiotensin system inhibitors before surgery.Copyright © 2024 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.

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