• Clinics · Jan 2025

    Evaluation of single-dose umbilical cord blood-derived mononuclear cell injection immediately and 7 days after spinal cord trauma in mice.

    • de AraujoAlex OliveiraAODepartment of Orthopedic Surgery, Rede SARAH de Hospitais de Reabilitação, (SMHS), Brasília, DF, Brazil. Electronic address: alexiotfmusp@gmail.com., Dos SantosGustavo BispoGBDepartment of Orthopedic Surgery, Instituto de Ortopedia e Traumatologia da Universidade de São Paulo, São Paulo, SP, Brazil., Raphael Martus Marcon, Maria Helena Alves Nicola, Marcela Saldanha Pereira, Fernando Barbosa Sanchez, AraujoThiego Pedro FreitasTPFDepartament of Orthopedic Surgery, Hospital Sírio Libanês, Brasília, DF, Brazil., and Alexandre Fogaça Cristante.
    • Department of Orthopedic Surgery, Rede SARAH de Hospitais de Reabilitação, (SMHS), Brasília, DF, Brazil. Electronic address: alexiotfmusp@gmail.com.
    • Clinics (Sao Paulo). 2025 Jan 30; 80: 100579100579.

    Study DesignExperimental study utilizing a standardized Balb C mouse model.ObjectivesEvaluate histological changes and motor function recovery in the acute and subacute phases of Spinal Cord Injury (SCI) in mice using human Umbilical cord blood-derived mononuclear cells.MethodsForty mice were divided into five groups, with two receiving human Umbilical cord blood-derived mononuclear cells immediately after SCI and after 7 days, and three control groups. Motor assessment utilized BMS, MFS, and horizontal plane scales over six weeks. Necropsy evaluated macroscopic and histological spinal cord changes.ResultsHistologically, Umbilical cord blood-derived mononuclear cells-treated groups exhibited significant reductions in necrosis, hemorrhage, and degeneration compared to controls. Motor recovery showed partial improvement across all groups, with no statistically significant differences in scales between intervention and control groups.ConclusionsIn the acute phases of SCI, Umbilical cord blood-derived mononuclear cells applied directly to Balb C mice lesions demonstrated histological improvement but played a limited role in functional enhancement. The study highlights distinctions in the treatment's efficacy, potentially related to these cells' diverse differentiation capacities and intrinsic properties.Copyright © 2025. Published by Elsevier España, S.L.U.

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