• Pak J Med Sci · Jan 2025

    Effect of Shengyang Yiwei Decoction combined with selective serotonin reuptake inhibitor antidepressants on HAMD-17 score and somatic symptoms in patients with depression.

    • Lin Li, Aihua Wan, Mingkun Zhao, Liyan Yu, Yanchao Han, and Kun Mi.
    • Lin Li, Integrated Traditional Chinese and Western Medicine Department, Hebei Provincial Mental Health Center, Baoding 071000, Hebei, China.
    • Pak J Med Sci. 2025 Jan 1; 41 (1): 205209205-209.

    ObjectiveTo investigate the efficacy of Shengyang Yiwei Decoction (SYD) combined with selective serotonin reuptake inhibitor(SSRI) antidepressants on the total score and scores of factors of the Hamilton Rating Scale for Depression(HAMD-17) and somatic symptoms in patients with depression.MethodsThis was a retrospective study. One hundred and twenty patients with depression were treated in Hebei Provincial Mental Health Center between December 2020 and May 2022 and randomly divided into the experimental group and the control group, with 60 patients in each group. Patients in the control group were treated with selective serotonin reuptake inhibitor (SSRI) antidepressants and those in the experimental group were treated with modified SYD in addition to SSRIs for eight weeks. Explored the efficacy and adverse drug reactions of the two treatment options.ResultsAfter eight weeks of treatment, there was no statistically significant difference in the total efficacy between the two groups(p>0.05); the total score of HAMD-17 and scores of factors except body weight were decreased in the experimental group compared with those in the control group, and the differences were statistically significant(p<0.05). The SSI score of the experimental group was decreased compared with that of the control group, and the difference was statistically significant(p<0.05).ConclusionSYD combined with SSRI antidepressants in the treatment of depression can reduce the total score and the scores of factors of HAMD-17 without increasing the incidence of adverse drug reactions. This combination can be used as an integrated traditional Chinese and Western medicine treatment for depression.Copyright: © Pakistan Journal of Medical Sciences.

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