• Fumiya Inoue, Takayuki Otani, Toshikazu Abe, Akihiko Inoue, Toru Hifumi, Tetsuya Sakamoto, Yasuhiro Kuroda, and SAVE-J II Study Group.
• Department of Emergency Medicine, Hiroshima City Hiroshima Citizens Hospital, Hiroshima-city, Hiroshima, Japan. Electronic address: fumiya.233832@gmail.com.
• J Emerg Med. 2025 Feb 1; 69: 1121-12.

BackgroundIntracranial hemorrhage (ICH) and acute aortic syndrome (AAS) are etiologies associated with unfavorable outcomes in patients with out-of-hospital cardiac arrest (OHCA), even with extracorporeal cardiopulmonary resuscitation (ECPR).ObjectivesThis study aimed to describe the characteristics of refractory OHCA patients resuscitated with ECPR due to ICH and AAS.MethodsThis was a descriptive study and a secondary analysis of the SAVE-J II study, which was a multicenter ECPR registry.ResultsAmong the 1589 cases, the causes of arrest were ICH in 48 patients (3%), AAS in 112 patients (7%), and cardiac causes in 1429 patients (90%). Patients in the ICH group were younger (ICH: 47 years [interquartile ranges (IQR) 40-63], AAS: 68 years [IQR 59-74], cardiac causes: 61 years [IQR 50-68]; p < 0.001), and had fewer signs of life on hospital arrival (ICH: 2%, AAS: 12%, cardiac causes: 19%; p = 0.001) compared to the cardiac causes group. Patients in the ICH and AAS groups were also less likely to present with an initial shockable rhythm (ICH, 19%; AAS, 27%; cardiac causes, 74%; p < 0.001). Survival to hospital discharge was significantly lower in the ICH and AAS groups than in the cardiac cause group (ICH, 4%; AAS, 4%; cardiac causes, 29%; p < 0.001). Of the 112 patients in the AAS group, 54 (48%) were presumptively diagnosed as cardiac etiologies before ECPR.ConclusionICH and AAS should be considered potential causes of cardiac arrest, especially in cases with a nonshockable initial cardiac rhythm. However, differentiating them from cardiac causes of arrest remains challenging.Copyright © 2024 Elsevier Inc. All rights reserved.

28 keywords...

hide…