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- Karlo Perica, Nayan Jain, Michael Scordo, Ruchi Patel, Ozgur Can Eren, Utsav Patel, Gunes Gundem, Dylan Domenico, Sneha Mitra, Nicholas D Socci, John K Everett, Aoife M Roche, Angelina Petrichenko, Gunjan L Shah, Maria E Arcila, Laetitia Borsu, Jae H Park, Steven M Horwitz, Sergio A Giralt, Ahmet Dogan, Christina Leslie, Elli Papaemmanuil, Frederic D Bushman, Saad Z Usmani, Michel Sadelain, and Sham Mailankody.
- Cellular Therapy Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York.
- N. Engl. J. Med. 2025 Feb 6; 392 (6): 577583577-583.
AbstractMalignant T-cell transformation after chimeric antigen receptor (CAR) T-cell therapy has been described, but the contribution of CAR integration to oncogenesis is not clear. Here we report a case of a T-cell lymphoma harboring a lentiviral integration in a known tumor suppressor, TP53, which developed in a patient with multiple myeloma after B-cell maturation antigen (BCMA) CAR T-cell therapy.Copyright © 2025 Massachusetts Medical Society.
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