• Denzel L Q Drop, Johan H Vlake, Evert-Jan Wils, Jasper Van Bommel, Christian Jung, Denise E Hilling, O Joseph Bienvenu, Tim I M Korevaar, Anna F C Schut, van MolMargo M CMMC0000-0002-0213-6054Department of... more Adult Intensive Care, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Diederik Gommers, and Michel E van Genderen. less
• Department of Adult Intensive Care, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
• Crit Care. 2025 Feb 5; 29 (1): 6262.

BackgroundRelatives of intensive care unit (ICU) patients often endure symptoms of post-traumatic stress, anxiety, and depression during and after treatment of a family member's hospitalization. The aim of this study was to evaluate the effect of ICU-specific virtual reality (ICU-VR) on mental health among relatives, 6 months after patient's ICU discharge.MethodsThis multicenter, randomized controlled trial included relatives of ICU patients who were assigned to receive either standard care or standard care plus ICU-VR, by randomizing the ICU patients. Relatives were assessed up to 6 months after patient discharge from the ICU for post-traumatic stress, anxiety, depression, quality of life, relatives' understanding of ICU care, and appreciation of ICU-VR.ResultsOne hundred relatives of 81 patients and 89 relatives of 80 patients were randomized to the intervention and control groups, respectively. Relatives' median age was 48 years and 53% were female. Compared to the control group, relatives who received ICU-VR did not experience a decrease in post-traumatic stress (23% vs. 18%; p = 0.99), anxiety (22% vs. 30%; p = 0.35), or depression (17% vs. 23%; p = 0.44). There was no significant difference between median mental quality of life (50.2 vs. 52.6; p = 0.51), physical quality of life (56.1 vs. 54.3; p = 0.16), or understanding of ICU care between groups. Patients in the intervention group highly endorsed ICU-VR (90%), favoring it over traditional informational brochures and the majority (82%) stated it improved their understanding of ICU treatment.ConclusionICU-VR did not significantly improve mental health distress symptoms among relatives 6-months after a patient's discharge. Relatives highly endorsed ICU-VR and self-reported that it improved their understanding of ICU treatment.© 2025. The Author(s).

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