• Resuscitation · Feb 2025

    Temporal Dynamics of Neural Synchrony and Complexity of Auditory EEG Responses in Post-Hypoxic Ischemic Coma.

    • Sigurd L Alnes, Florence M Aellen, Thomas Rusterholz, Andria Pelentritou, Matthias Hänggi, Andrea O Rossetti, Frédéric Zubler, LuciaMarzia DeMLaboratory for Research in Neuroimaging (LREN), Department of Clinical Neurosciences, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland; Center for Biomedical Imaging (CIBM), Lausanne, Switzerland., and Athina Tzovara.
    • Institute of Computer Science, University of Bern; Center for Experimental Neurology and Sleep Wake Epilepsy Center-NeuroTec, Department of Neurology, Inselspital, Bern University Hospital, University of Bern.
    • Resuscitation. 2025 Feb 7: 110531110531.

    AbstractThe capacity to integrate information across brain regions and sufficient diversity of neural activity is necessary for consciousness. In patients in a post-hypoxic ischemic coma, the integrity of the auditory processing network is indicative of chances of regaining consciousness. However, our understanding of how measures of integration and differentiation of auditory responses manifest across time of coma is limited. We investigated the temporal evolution of neural synchrony of auditory-evoked electroencephalographic (EEG) responses, measured via their phase-locking value (PLV), and of their neural complexity in unconscious post-hypoxic ischemic comatose patients. Our results show that the PLV was predictive of chances to regain consciousness within the first 40 hours post-cardiac arrest, while its predictive value diminished over subsequent time after coma onset. This was due to changing trajectories of PLV over time of coma for non-survivors, while survivors had stable PLV. The complexity of EEG responses was not different between patients who regained consciousness and those who did not, but it significantly diminished over time of coma, irrespective of the patient's outcome. Our findings provide novel insights on the optimal temporal window for assessing auditory functions in post-hypoxic ischemic coma. They are of particular importance for guiding the implementation of quantitative techniques for prognostication and contribute to an evolving understanding of neural functions within the acute comatose state.Copyright © 2025 The Author(s). Published by Elsevier B.V. All rights reserved.

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