• Antonio José Madueño-Caro, Gonzalo Berro-Ramírez, Luis Chávez-Gata, Rubén Torrescusa-Camisón, José Antonio Climent-Rodríguez, Yolanda Navarro-Abal, and Juan Gómez-Salgado.
• Centro de salud La Laguna. Servicio Andaluz de Salud, Cádiz, España.
• Aten Primaria. 2025 Feb 12; 57 (8): 103234103234.

ObjectiveTo determine the variables associated with the prescription of long-term antidepressants (more than three years) to patients in a primary health area.DesignDescriptive observational study. SITE: Basic health area of primary care.ParticipantsA sample of 315 participants assigned to a basic health area, who have been prescribed at least one antidepressant during a calendar year.InterventionsInstitutional information sources.Main MeasurementsThose variables that can be associated with a prolonged prescription of antidepressants. The selection of the patients was carried out by simple random sampling. Analysis using Chi-Square contrast for the comparison of proportions. Multivariate binary logistic regression to observe possible associations in the set of variables.ResultsThe study analyzed a majority of women (75.2%) with a mean age of 61.7 years (SD=38.18). SSRIs (Selective Serotonin Reuptake Inhibitors) were the most commonly used antidepressants (50.5%), especially sertraline. Dysthymia was the main diagnosis (17%). Prolonged duration of treatment was associated with SSRIs and dysthymia. Logistic regression showed relevant factors: dysthymia, age, number of antidepressants, and SSRI use.ConclusionThere is a high prevalence of prescription beyond three years. It is observed how dysthymic disorder is associated with a prolonged duration of treatment, as well as age, SSRI use, antidepressant change, and the total number of antidepressants prescribed.Copyright © 2025 The Author(s). Publicado por Elsevier España S.L.U. All rights reserved.

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