• Jesse Lou, Rabiul Ryan, and Dajie Wang.
• Department of Anesthesiology, Jefferson Pain Center, Sidney Kimmel Medical College at Thomas ,Jefferson University, Philadelphia, PA, U.S.A.
• Curr Pain Headache Rep. 2025 Feb 11; 29 (1): 4545.

Purpose Of ReviewThe purpose of this review is to provide an update on recent developments in the field of regenerative medicine, specifically focusing on emerging data related to biologics, including platelet-rich plasma and mesenchymal cells, for the treatment of discogenic back pain.Recent FindingsThere has been a notable surge of interest in biologics, as evidenced by a wealth of recent reviews and studies. While serious adverse events are generally uncommon, considerable heterogeneity exists in study designs. More robust investigations are warranted to thoroughly evaluate the safety and efficacy of biologics in treating discogenic back pain. Continued research and funding are needed to better understand the underlying mechanisms of disc degeneration and to develop targeted therapies that can alleviate and reduce the burden of this debilitating condition. Biologics may offer effective treatments for discogenic pain; however, more multi-center, prospective, double-blinded, randomized placebo-controlled trials are essential to further establish their effectiveness.© 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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