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- Motoyasu Kan, Yoshiki Ogane, Kazuki Watabe, Tomoya Takahashi, Miho Sakai, Yu Sekine, Nana Yamada, Chihei Sugihara, Mayu Ouchi, Hiroki Nagashima, Koji Takahashi, Koichiro Okitsu, Hiroshi Ohyama, Izumi Ohno, and Naoya Kato.
- Department of Gastroenterology, Graduate School of Medicine, Chiba University, Japan.
- Intern. Med. 2025 Feb 8.
AbstractCancer cachexia, which is characterized by weight loss and muscle weakness, is common in patients with pancreatic cancer. Anamorelin, a ghrelin receptor agonist, has shown potential for the management of cachexia in various cancers. We herein report a 64-year-old man with unresectable pancreatic cancer who experienced significant weight gain with anamorelin, allowing for continued chemotherapy and an improved quality of life. Despite disease progression, his response suggests the potential utility of anamorelin as a supportive therapy. Cachexia's complex metabolic changes make treatment difficult; however, anamorelin's appetite and weight gain effects highlight its possible role in managing cachexia in pancreatic cancer. Therefore, further research is required in this regard.
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