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- Yuichi Horigome, Shunsuke Ishii, Manabu Matsumoto, Yoshihiko Ikeda, Kinta Hatakeyama, Junya Ako, and Takahiro Suzuki.
- Department of Hematology, Kitasato University School of Medicine, Japan.
- Intern. Med. 2025 Feb 8.
AbstractCardiac amyloidosis (CA), predominantly caused by amyloid transthyretin (ATTR) or immunoglobulin light chain (AL), has a poor prognosis, and a precise diagnosis is crucial because the optimal treatments differ between the two conditions. However, diagnosing AL-CA is challenging because of the unavailability of effective AL-detecting antibodies, particularly in cases with coexisting AL- and ATTR-CA. This report presents a successfully diagnosed case of complicated AL- and ATTR-CA that was successfully treated with tafamidis for ATTR-CA and combination chemotherapy for AL-CA. This case highlights the importance of a precise diagnosis of CA and supports the efficacy and safety of concurrent treatment for coexisting amyloidosis.
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