• Am. J. Med. Sci. · Feb 2025

    Review

    Facial Metastasis of Esophageal Squamous Cell Carcinoma.

    • Sen-Ei Shai, Hung-Ju Kuo, Yi-Ling Lai, and Chi-Wei Hsieh.
    • Department of Thoracic Surgery, Taichung Veterans General Hospital, Taichung, 407219, Taiwan; 1650 Taiwan Boulevard Sect. 4, Taichung, Taiwan, 407219; Department of Applied Chemistry, National Chi Nan University, Nantou, 545301, Taiwan; No. 1, Daxue Rd., Puli Township, Nantou, Taiwan, 545301; Institute of Clinical Medicine, National Yang-Ming Chiao-Tung University, Taipei, 112304, Taiwan; No. 155, Sec. 2, Linong St. Beitou Dist., Taipei, Taiwan, 112304. Electronic address: sse50@yahoo.com.
    • Am. J. Med. Sci. 2025 Feb 10.

    AbstractEsophageal squamous cell carcinoma (SCC) is a highly lethal malignancy with a low survival rate, often presenting at an advanced stage. Cutaneous metastasis from esophageal SCC is exceedingly rare, affecting less than 1% of cases, and is associated with a poor prognosis. This review particularly focuses on facial metastasis and discusses the clinical presentation, diagnostic challenges, and management of cutaneous metastases. The variability in clinical presentation often leads to misdiagnosis, delaying appropriate treatment. Histopathological examination and immunohistochemical staining are crucial for accurate diagnosis. Management involves a combination of local and systemic therapies, tailored to the patient's overall health and disease extent. This topic emphasizes the need for vigilance and thorough diagnostic workups in patients with unusual skin lesions and highlights the importance of multidisciplinary care in optimizing treatment outcomes for patients with advanced esophageal cancer.Copyright © 2025. Published by Elsevier Inc.

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