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Anesthesia and analgesia · May 1987
Randomized Controlled Trial Comparative Study Clinical TrialLocal analgesia without anesthesia using peripheral perineural morphine injections.
- K S Mays, J J Lipman, and M Schnapp.
- Anesth. Analg. 1987 May 1;66(5):417-20.
AbstractTwenty-five patients with chronic pain were treated with nerve blocks. They were divided into two groups, A and B, according to the volume of local anesthetic required for surgical anesthesia by standard nerve block techniques. The 16 patients in group A had pain in the distribution of small nerves, which could be blocked with 5 ml or less. They were blocked in a random, double-blind crossover fashion using 0.5% bupivacaine or 0.02% morphine. The nine patients in group B were injected simultaneously with saline, 30 ml perineurally and 1 ml intramuscularly. Morphine (6 mg) was added, in a random, double-blind fashion, to one of the injections. A second pair of injections was subsequently done, using morphine by the alternative route. Perineural morphine provided statistically longer lasting pain relief than did either intramuscular morphine or perineural bupivacaine.
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