• Lise Bergman Nordgren, Erik Hedman, Julie Etienne, Jessica Bodin, Asa Kadowaki, Stina Eriksson, Emelie Lindkvist, Gerhard Andersson, and Per Carlbring.
• Department of Behavioural Sciences and Learning, Linköping University, SE-581 83 Linköping, Sweden. Electronic address: lise.bergman.nordgren@liu.se.
• Behav Res Ther. 2014 Aug 1;59:1-11.

UnlabelledA significant proportion of the general population suffers from anxiety disorders, often with comorbid psychiatric conditions. Internet-delivered cognitive behavior therapy (ICBT) has been found to be a potent treatment for patients with specific psychiatric conditions. The aim of this trial was to investigate the effectiveness and cost-effectiveness of ICBT when tailoring the treatment to address comorbidities and preferences for primary-care patients with a principal anxiety disorder. One hundred participants were recruited through their primary-care contact and randomized to either treatment or an active control group. The treatment consisted of 7-10 weekly individually assigned modules guided by online therapists. At post-treatment, 46% of the treatment group had achieved clinically significant improvement on the primary outcome measure (CORE-OM) and between-group effect sizes ranged from d = 0.20 to 0.86, with a mean effect of d = 0.59. At one-year follow-up, within-group effect sizes varied between d = 0.53 to 1.00. Cost analysis showed significant reduction of total costs for the ICBT group, the results were maintained at one-year follow-up and the incremental cost-effectiveness ratio favored ICBT compared to control group. Individually tailored ICBT is an effective and cost-effective treatment for primary-care patients with anxiety disorders with or without comorbidities.Trial RegistrationClinicaltrials.gov: NCT01390168.Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

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