• Eur. J. Clin. Pharmacol. · May 2011

    Review

    Endpoints in pediatric pain studies.

    • Monique van Dijk, Ilse Ceelie, and Dick Tibboel.
    • Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, Netherlands.
    • Eur. J. Clin. Pharmacol. 2011 May 1;67 Suppl 1:61-6.

    AbstractAssessing pain intensity in (preverbal) children is more difficult than in adults. Tools to measure pain are being used as primary endpoints [e.g., pain intensity, time to first (rescue) analgesia, total analgesic consumption, adverse effects, and long-term effects] in studies on the effects of analgesic drugs. Here, we review current and promising new endpoints used in pediatric pain assessment studies.

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