• A Blümle, G Antes, and M K Diener.
• Deutsches Cochrane Zentrum, Abteilung für Medizinische Biometrie und Statistik, Institut für Medizinische Biometrie und Informatik, Universitätsklinikum, Stefan-Meier-Strasse 26, Freiburg, Germany. bluemle@cochrane.de
• Chirurg. 2007 Nov 1;78(11):1052-7.

BackgroundThe identification of all available and relevant study reports is mandatory for a comprehensive assessment of randomised (RCTs) and controlled clinical trials (CCTs) in systematic reviews. Incomplete compilation of health care journals in electronic databases and incorrect indexing of the studies impair the result of a systematic literature search. An additional search in medical journals that are not listed in electronic databases can obtain higher search precision.MethodsIn the hand searching project of the Cochrane Collaboration, in Germany 14 surgical journals were searched manually for RCTs and CCTs. The identified study reports were compared with Medline records, and the publication frequency was analysed. The study reports were published in the Cochrane Library and are henceforth available for inclusion in systematic reviews.ResultsFour hundred (77%) of the 519 published volumes in the 14 surgical journals were searched for RCTs and CCTs. Of the 1152 controlled trials (670 RCTs and 482 CCTs) identified, 674 (58%) were not included in Medline.ConclusionsThe gap between the number of hand search results and the number of Medline indexed RCTs and CCTs is also reflected in other special medical fields. To ensure completeness of the literature compilation, the hand searching project should be continued.

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