• Hege Kristin Brekke, Stig Morten Hammersborg, Steinar Lundemoen, Arve Mongstad, Venny Lise Kvalheim, Oddbjørn Haugen, and Paul Husby.
• * Research Fellow, Department of Anesthesia and Intensive Care, † Research Fellow, ‡ Research Assistant, § Associate Professor, Section for Thoracic Surgery, Department of Heart Disease, Haukeland University Hospital, Bergen, Norway. ‖ Post-doctor, Department of Anesthesia and Intensive Care, # Professor, Department of Clinical Medicine, University of Bergen, Haukeland University Hospital.
• Anesthesiology. 2013 Oct 1;119(4):861-70.

BackgroundA highly positive intraoperative fluid balance should be prevented as it negatively impacts patient outcome. Analysis of volume-kinetics has identified an increase in interstitial fluid volume after crystalloid fluid loading during isoflurane anesthesia. Isoflurane has also been associated with postoperative hypoxemia and may be associated with an increase in alveolar epithelial permeability, edema formation, and hindered oxygen exchange. In this article, the authors compare fluid extravasation rates before and during cardiopulmonary bypass (CPB) with isoflurane- versus propofol-based anesthesia.MethodsFourteen pigs underwent 2 h of tepid CPB with propofol (P-group; n = 7) or isoflurane anesthesia (I-group; n = 7). Fluid requirements, plasma volume, colloid osmotic pressures in plasma and interstitial fluid, hematocrit levels, and total tissue water content were recorded, and fluid extravasation rates calculated.ResultsFluid extravasation rates increased in the I-group from the pre-CPB level of 0.27 (0.13) to 0.92 (0.36) ml·kg·min, but remained essentially unchanged in the P-group with significant between-group differences during CPB (pb = 0.002). The results are supported by corresponding changes in interstitial colloid osmotic pressure and total tissue water content.ConclusionsDuring CPB, isoflurane, in contrast to propofol, significantly contributes to a general increase in fluid shifts from the intravascular to the interstitial space with edema formation and a possible negative impact on postoperative organ function.

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