• Ilse F de Coo, Leopoldine A Wilbrink, and Joost Haan.
• Department of Neurology Leiden University Medical Centre, Leiden, The Netherlands, i.f.de_coo@lumc.nl.
• Curr Pain Headache Rep. 2015 Aug 1; 19 (8): 39.

AbstractTrigeminal autonomic cephalalgias (TACs) are primary headache syndromes that share some clinical features such as a trigeminal distribution of the pain and accompanying ipsilateral autonomic symptoms. By definition, no underlying structural lesion for the phenotype is found. There are, however, many descriptions in the literature of patients with structural lesions causing symptoms that are indistinguishable from those of idiopathic TACs. In this article, we review the recent insights in symptomatic TACs by comparing and categorizing newly published cases. We confirm that symptomatic TACs can have typical phenotypes. It is of crucial importance to identify symptomatic TACs, as the underlying cause will influence treatment and outcome. Our update focuses on when a structural lesion should be sought.

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