• Clinics in chest medicine · Dec 2008

    Review

    Management of sepsis: early resuscitation.

    • Emanuel P Rivers, Victor Coba, Alvaro Visbal, Melissa Whitmill, and David Amponsah.
    • Department of Emergency Medicine, Henry Ford Health Systems, 270-Clara Ford Pavilion, 2799 West Grand Boulevard, Detroit, MI 48202, USA. erivers1@hfhs.org
    • Clin. Chest Med. 2008 Dec 1;29(4):689-704, ix-x.

    AbstractKey links in the chain of survival for the management of severe sepsis and septic shock are early identification and comprehensive resuscitation of high-risk patients. Multiple studies have shown that the first 6 hours of early sepsis management are especially important from a diagnostic, pathogenic, and therapeutic perspective, and that steps taken during this period can have a significant impact on outcome. The recognition of this critical time period and the robust outcome benefit realized in previous studies provides the rationale for adopting early resuscitation as a distinct intervention. Sepsis joins trauma, stroke, and acute myocardial infarction in having "golden hours," representing a critical opportunity early on in the course of disease for actions that offer the most benefit.

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