• Zhongguo Wei Zhong Bing Ji Jiu Yi Xue · Oct 2012

    Randomized Controlled Trial

    [Effect of prone position on the oxygenation of patients with acute respiratory distress syndrome after failure recruitment maneuvers at high altitudes].

    • Wen-xin Wang, Bo Xu, Hu-sai Ma, and Jian-bin Meng.
    • Department of Intensive Care Unit, Qinghai Red Cross Hospital, Qinghai, China. wangwenxindongying@163.com
    • Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2012 Oct 1;24(10):596-9.

    ObjectiveTo assess the effect of prone position on the oxygenation of patients with acute respiratory distress syndrome (ARDS) after recruitment maneuvers (RM) failure at high altitudes.MethodsForty-one ARDS patients who were invalid for RM therapy at the altitude of 2260 metres area hospital were enrolled[mean oxygenation index (PaO(2)/FiO(2)) increased than RM<20% considered as RM invalid]. All were divided into acute respiratory distress syndrome (ARDSp) and extra-acute respiratory distress syndrome (ARDSexp) based on different etiology, and each group was randomly divided into the supine and the prone position group, i.e. that ARDSp prone position group (n=11), ARDSp supine group (n=9), ARDSexp prone position group (n=10), and ARDSexp supine group (n=11). Before ventilation and 1, 2, 3, 4 hours after ventilation, arterial partial pressure of oxygen (PaO(2)), PaO(2)/FiO(2), static lung compliance (Cst), airway resistance (Raw) were monitored.ResultsOne hour after ventilation in ARDSexp prone position group, PaO(2)/FiO(2) was significantly higher than before ventilation (157.4±40.6 mm Hg vs. 129.3±48.7 mm Hg, P<0.05), and increased by ventilation time, peaked at 4 hours (219.1±41.1 mm Hg). Within 3 hours ventilation in ARDSexp prone position group, PaO(2)/FiO(2) was significantly higher compared with the other three groups, and there were no significant differences among the other three groups. PaO(2)/FiO(2) in ARDSp prone position group and ARDSexp prone position group at 4 hours of ventilation were significantly higher compared with the corresponding supine group (208.8±39.7 mm Hg vs. 127.4±47.1 mm Hg, 219.1±41.1 mm Hg vs. 124.9±50.8 mm Hg, both P<0.05). There was no statistically significant difference in Cst before and after ventilation, and there was no significant changes among the groups. Raw in ARDSp prone position group at 4 hours of ventilation were significantly reduced than before ventilation (6.8±1.7 cm H(2)O×L(-1)×s(-1) vs. 10.7±1.8 cm H(2)O×L(-1)×s(-1), P<0.05), and significantly lower than the other three groups. There was no statistically significant difference in RAW among other three groups at each time point.ConclusionProne position can improve RM oxygenation invalid ARDS patients at high altitudes.

      Pubmed     Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…