• J Clin Neurosci · Apr 2014

    Review Case Reports

    Valproate induced hyperammonemic encephalopathy successfully treated with levocarnitine.

    • Andrea Rigamonti, Giuseppe Lauria, Gianluca Grimod, Graziella Bianchi, and Andrea Salmaggi.
    • Department of Neurology, Alessandro Manzoni Hospital, Via Dell'Eremo 9/11, 23900 Lecco, Italy. Electronic address: rig74@libero.it.
    • J Clin Neurosci. 2014 Apr 1;21(4):690-1.

    AbstractValproate-induced hyperammonemic encephalopathy is an unusual but serious adverse effect that is usually characterized by the acute onset of impaired consciousness, focal neurological symptoms and increased seizure frequency. It has been reported to occur at therapeutic valproate levels. We report a patient who developed valproate-induced hyperammonemic encephalopathy after a short treatment with valproate and was successfully treated with levocarnitine. We discuss this patient and review the literature regarding the use of levocarnitine in similar patients.Copyright © 2013 Elsevier Ltd. All rights reserved.

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