• Anaesth Intensive Care · Dec 1999

    Randomized Controlled Trial Comparative Study Clinical Trial

    A comparison of patient controlled epidural pethidine versus single dose epidural morphine for analgesia after caesarean section.

    • M P Fanshawe.
    • Department of Anaesthesia and Intensive Care, Redcliffe Hospital, Brisbane, Queensland.
    • Anaesth Intensive Care. 1999 Dec 1;27(6):610-4.

    AbstractThis double-blind, randomized study of analgesia after caesarean section compared patient controlled epidural analgesia with pethidine (15 mg of a 0.25% solution and a 10 minute lockout period) versus a single bolus of epidural morphine 4 mg. Data were collected on 78 patients at 2, 6, 8, and 24 hours postoperatively and analysed using the Wilcoxon rank sum test. Satisfactory analgesia and nausea/vomiting during the first twenty-four hours did not differ between the two groups. The incidence of pruritus (P < 0.001) was lower in the pethidine group at 2, 6, and 8 hours, with no difference by 24 hours. Therefore PCEA pethidine provides a useful alternative to single-dose morphine after caesarean section, particularly in those patients who have suffered severe morphine-induced pruritus previously.

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