• H Bryant Nguyen, Elizabeth Lea Lynch, Joshua A Mou, Kristopher Lyon, William A Wittlake, and Stephen W Corbett.
• Department of Emergency Medicine, Loma Linda University, Loma Linda, CA, USA. hbnguyen@llu.edu
• Acad Emerg Med. 2007 Nov 1;14(11):1079-86.

AbstractThe research in the management of severe sepsis and septic shock has resulted in a number of therapeutic strategies with significant survival benefits. These results also emphasize the primary importance of early hemodynamic resuscitation, or early goal-directed therapy (EGDT), and place the emergency physician in the center of the multidisciplinary team caring for patients with this disease. However, in a busy emergency department, the translation of research into clinical practice is far from ideal. While the benefits are significant, the successful implementation of EGDT is filled with challenges and obstacles. In this article, we will discuss the steps taken at our institution to create, implement, measure, and improve on a six-hour severe sepsis and septic shock treatment bundle incorporating EGDT in the emergency department setting, resulting in significant mortality benefit.

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