• Minerva anestesiologica · Jun 2007

    Randomized Controlled Trial

    Postoperative vomiting reduction after laparoscopic cholecystectomy with single dose of dexamethasone.

    • A Bianchin, A De Luca, and A Caminiti.
    • Anesthesia Department, ASL 8 Asolo, G. Carretta City Hospital, Montebelluna, Treviso, Italy. andbia@libero.it
    • Minerva Anestesiol. 2007 Jun 1;73(6):343-6.

    AimThe incidence of postoperative nausea and vomiting (PONV) is high after laparoscopic surgery. A number of drugs have been used for prevention; in some studies a single dexamethasone dose before induction of anaesthesia has been effective.MethodsTo test the effectiveness of this therapy, we recruited 80 patients in a double-blind placebo-controlled study (dexamethasone 8 mg or placebo) scheduled for laparoscopic cholecystectomy. We measured nausea, vomiting, postoperative pain and length of stay.ResultsPatients who received preoperative dexamethasone had a reduction of PONV, but experienced the same degree of postoperative pain and remained in the hospital for the same duration. No apparent side effects were observed.ConclusionAlthough only a small number of patients were tested, we confirm the efficacy of dexamethasone therapy for reduction of PONV. We suggest routine use of a single dose of dexamethasone for the prevention of PONV in laparoscopic cholecystectomy.

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