• Chest · Feb 2013

    Review

    T helper 17 cells in airway diseases: from laboratory bench to bedside.

    • Rabih Halwani, Saleh Al-Muhsen, and Qutayba Hamid.
    • Prince Naif Center for Immunology Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
    • Chest. 2013 Feb 1;143(2):494-501.

    AbstractT helper 17 (Th17) cytokines are now widely believed to be critical for the regulation of various chronic immune diseases. Investigations have revealed a significant role for IL-17 cytokines in regulating inflammation and modulating lung and airway structural cells in asthma and COPD. In this review, our current understanding of the role of Th17-associated cytokines in airway diseases is summarized. Therapeutic approaches targeting IL-17 during asthma and COPD are also discussed.

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