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J Am Anim Hosp Assoc · Jul 2011
Case ReportsFailure to reverse prolonged vecuronium-induced neuromuscular blockade with edrophonium in an anesthetized dog.
- Manuel Martin-Flores, Jordyn Boesch, Luis Campoy, and Robin D Gleed.
- Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
- J Am Anim Hosp Assoc. 2011 Jul 1;47(4):294-8.
AbstractA case of prolonged muscle relaxation after vecuronium in an anesthetized dog is presented. After using peripheral nerve stimulation to confirm partial recovery of neuromuscular transmission, administration of 0.5 mg/kg IV of intravenous edrophonium failed to complete the reversal process. Subsequent administration of neostigmine resulted in complete recovery from blockade. Without monitoring neuromuscular function with a peripheral nerve stimulator until reversal was complete, it was very likely this patient would have been extubated with incomplete neuromuscular transmission. Several factors affecting the duration of neuromuscular blockade and its reversal are addressed.
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