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- D M Miranda, M A Romano-Silva, E Kalapothakis, C R Diniz, M N Cordeiro, T M Santos, M A Prado, and M V Gomez.
- Departmento de Farmacologia, ICB-UFMG, Belo Horizonte-MG, Brasil.
- Neuroreport. 1998 May 11;9(7):1371-3.
AbstractNeurotoxins can help the understanding of mechanisms involved in neurotransmission. We here report that two neurotoxin isoforms, Tx3-3 and Tx3-4 obtained from the venom of the spider Phoneutria nigriventer inhibited the 45Ca2+ influx in rat cortical synaptosomes induced by the scorpion venom tityustoxin. The IC50 for Tx3-3 and Tx3-4 were 0.32 and 7.9 nM, respectively. The neurotoxins Tx3-3 and Tx3-4 are very effective in inhibiting 45Ca2+ influx and they should be useful in studies involving Ca(2+)-dependent processes.
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