• Heart failure clinics · Apr 2013

    Review

    Brain-heart interaction in takotsubo cardiomyopathy.

    • Judith Z Goldfinger, Ajith Nair, and Brett A Sealove.
    • Cardiovascular Institute, Mount Sinai Medical Center, 1 Gustave L. Levy Place, Box 1030, New York, NY 10029, USA.
    • Heart Fail Clin. 2013 Apr 1;9(2):217-23, ix.

    AbstractTakotsubo cardiomyopathy is classically stress induced and characterized by regional wall motion abnormalities in the absence of coronary occlusion. It predominantly affects postmenopausal women; emotional and physical stressors can trigger the classic cardiomyopathic findings. These changes are likely mediated by catecholamines, which cause a distinctive pattern of ventricular dysfunction with a unique pathologic phenotype of apical ballooning. Underlying mood disorders increase the risk for developing takotsubo cardiomyopathy after a triggering event. Takotsubo cardiomyopathy is one of several brain-heart disorders; its unique pathology can shed light on the complex interactions between the brain, sympathetic nervous system, and the cardiovascular system.Crown Copyright © 2013. Published by Elsevier Inc. All rights reserved.

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