• Arch Intern Med · Nov 1991

    Case Reports

    A case of propylene glycol toxic reaction associated with etomidate infusion.

    • E Bedichek and B Kirschbaum.
    • Department of Medicine, Medical College of Virginia, Richmond 23298-0160.
    • Arch Intern Med. 1991 Nov 1;151(11):2297-8.

    AbstractFor the treatment of postoperative seizures and prevention of brain edema, an etomidate drip was used in conjunction with phenytoin, diazepam, pentobarbital, and phenobarbital in a 70-year-old woman. During a period of 24 hours, the patient received in excess of 479 g of propylene glycol, which was present at 35% (vol/vol) concentration in the undiluted etomidate. The propylene glycol toxic reaction resolved after the infusion was stopped.

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