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- S Pappata, M Levasseur, R N Gunn, R Myers, C Crouzel, A Syrota, T Jones, G W Kreutzberg, and R B Banati.
- INSERM U334, Service Hospitalier Frédéric Joliot, Orsay, France. pappata@shfj.cea.fr
- Neurology. 2000 Oct 10;55(7):1052-4.
AbstractUsing quantitative PET, the authors studied the binding of [11C]PK11195, a marker of activated microglia, in the thalamus of patients with chronic middle cerebral artery infarcts. All patients showed increased [11C]PK11195 binding in the ipsilateral thalamus, indicating the activation of microglia in degenerating projection areas remote from the primary lesion. A persistent increase in [11C]PK11195 binding suggests active, long-term thalamic microstructural changes after corticothalamic connection damage.
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