• Int. J. Antimicrob. Agents · Dec 2005

    Randomized Controlled Trial Multicenter Study Comparative Study

    Linezolid reduces length of stay and duration of intravenous treatment compared with vancomycin for complicated skin and soft tissue infections due to suspected or proven methicillin-resistant Staphylococcus aureus (MRSA).

    • Kamal M F Itani, John Weigelt, Jim Z Li, and Sandeep Duttagupta.
    • Boston VA Health Care System and Boston University, Boston, MA, USA.
    • Int. J. Antimicrob. Agents. 2005 Dec 1;26(6):442-8.

    AbstractWe compared the health outcomes in patients treated with linezolid or vancomycin for complicated skin and soft tissue infections (cSSTIs). This analysis is part of a randomised, open-label, multinational trial involving 1200 adult patients hospitalised with cSSTIs due to suspected or proven methicillin-resistant Staphylococcus aureus (MRSA). Subjects received linezolid 600 mg intravenous (i.v.) or oral, or vancomycin 1g i.v. every 12 h. A test-of-cure was assessed at 7 days post therapy. Compared with vancomycin, linezolid treatment was associated with significantly shorter length of stay (all P < 0.01), decreased i.v. antibiotic treatment duration (all P < 0.0001) and higher discharge rates (all P < 0.05). Thus, linezolid has the potential to reduce medical resource use for the treatment of cSSTIs.

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