• Christopher J Groombridge, Darrel Duplooy, Brandon D Adams, Eldho Paul, and Warwick Butt.
• Intensive Care Unit, Alfred Hospital, Melbourne, VIC, Australia. cgroombridge@doctors.org.uk
• Crit Care Resusc. 2011 Sep 1;13(3):151-5.

ObjectiveTo compare venous pressure and haemoglobin oxygen saturation measured from a catheter in the superior vena cava (SVC) with a catheter inserted via the femoral vein, and to assess the agreement of these measurements. To assess the effect of intra-abdominal pressure and intrathoracic pressures on these measurements.Design, Setting And ParticipantsProspective study of patients in an adult intensive care unit, Alfred Hospital, Melbourne, Australia.Main Outcome MeasuresCentral venous pressure (CVP), femoral venous pressure (FVP), venous haemoglobin oxygen saturation in the SVC (SO₂C) and via the femoral vein (SO₂F), agreement between these measures using the Bland-Altman method, and the effect of intra-abdominal pressure and intrathoracic pressure.Results43 patients were included; the mean bias for FVP -CVP was 1.05 mmHg (95% CI, 0.30-1.79 mmHg), with limits of agreement of -3.79 to 5.89 mmHg (95% CI, -5.08 to 7.18 mmHg). The bias for SO₂F -SO₂C was -3.21 (95% CI, -6.33 to -0.10), with limits of agreement of -22.43 to 16.01 (95% CI, -27.81 to 21.39). Intra-abdominal pressure had a significant (P < 0.01) effect on both the FVP and on the difference (FVP -CVP).ConclusionsThis study demonstrates poor agreement between CVP and FVP and between SO₂C and SO₂F and that the measurements taken from these two sites are not interchangeable clinically.

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