• Inflamm. Res. · Jan 2013

    Review

    Endothelial progenitor cells: the promise of cell-based therapies for acute lung injury.

    • Mei Mao, Xilin Xu, Yong Zhang, Bo Zhang, and Zu-Hong Fu.
    • Department of Respiratory Medicine, No 324 Hospital of PLA, Chongqing, China. maomei270@163.com
    • Inflamm. Res. 2013 Jan 1;62(1):3-8.

    BackgroundEndothelial progenitor cells (EPCs) are defined as a special type of stem cell that have been found to directly incorporate into injured vessels and that participate in angiogenesis and reconstruction by differentiation into endothelial cells. EPCs are widely used to therapeutically treat cardiovascular disease, limb ischemia and vascular repair. However, the role of EPCs in inflammatory diseases, especially in lung injury, is less studied.ObjectiveTo investigate the application of EPCs to vascular repair, and the role of EPCs in acute lung injury (ALI) and acute respiratory distress syndrome (ARDS).MethodsA computer-based online search was performed in the PubMed database and Web of Science database for articles published, concerning EPCs, angiogenesis, ALI/ARDS and stem cell transplantationConclusionEPCs have a therapeutic potential for vascular regeneration and may emerge as novel strategy for the diseases that are associated with ALI/ARDS.

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