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Randomized Controlled Trial Comparative Study Clinical Trial
Tetracaine, epinephrine (adrenalin), and cocaine (TAC) versus lidocaine, epinephrine, and tetracaine (LET) for anesthesia of lacerations in children.
- C G Schilling, D E Bank, B A Borchert, M D Klatzko, and D L Uden.
- Clinical Pharmacy Department, Minneapolis Children's Medical Center, Minnesota.
- Ann Emerg Med. 1995 Feb 1;25(2):203-8.
Study ObjectiveTo compare the duration of anesthesia experienced with lidocaine, epinephrine, and tetracaine (LET) solution and that with tetracaine, epinephrine (Adrenalin), and cocaine (TAC) solution during suturing of uncomplicated lacerations on the face or scalp.DesignDouble-blind, randomized, controlled trial.SettingThe emergency department of a university-affiliated private children's hospital.ParticipantsOne hundred seventy-one children with lacerations on the face and scalp requiring suturing.InterventionsAfter standard application of the anesthetic solution, patients were assessed for signs of discomfort before and during laceration repair. Duration of anesthesia during laceration repair was determined on the basis of the length of time after removal of the anesthetic solution to the first sign(s) of discomfort that required additional anesthesia.ResultsThere was no statistical difference between TAC and LET in adequacy of anesthesia before suturing or in duration of anesthesia during suturing.ConclusionLET is an effective alternative to TAC for topical anesthesia during suturing of uncomplicated lacerations on the face and scalp in children.
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