• David A Caro, Steven Andescavage, Mohsen Akhlaghi, Colleen Kalynych, and Robert L Wears.
• Department of Emergency Medicine, University of Florida College of Medicine–Jacksonville, Jacksonville, FL, USA. david.caro@jax.ufl.edu
• Ann Emerg Med. 2011 Mar 1;57(3):234-7.

Study ObjectiveWe determine whether pharmacologic neuromuscular blockade with succinylcholine or rocuronium during emergency rapid sequence intubation affects pupillary response to light.MethodsThis was a prospective case series of patients undergoing rapid sequence intubation between February 2008 and February 2009. Two blinded, independent emergency physicians assessed pupillary response after administration of neuromuscular blockade and intubation. Cases without pupillary response before rapid sequence intubation were excluded. The primary outcome measure was clinically observable pupillary response.ResultsWe studied 94 patients undergoing rapid sequence intubation, including 67 (71%) receiving succinylcholine and 27 (31%) receiving rocuronium. Of patients receiving succinylcholine, 61 of 67 (91%; 95% confidence interval 82% to 97%) demonstrated pupillary response after rapid sequence intubation. All patients receiving rocuronium demonstrated preserved pupillary reflexes. κ For interobserver agreement was 0.66.ConclusionSuccinylcholine and rocuronium do not appear to inhibit pupillary response in patients undergoing emergency department rapid sequence intubation.Copyright © 2010 American College of Emergency Physicians. Published by Mosby, Inc. All rights reserved.

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