• Am J Phys Med Rehabil · Dec 2007

    Case Reports

    Persistent hiccup associated with intrathecal morphine infusion pump therapy.

    • Xiulu Ruan, John Patrick Couch, Rinoo Shah, Frank Wang, and Hai Nan Liu.
    • Physicians' Pain Specialists of Alabama, Mobile, Alabama 36607, USA.
    • Am J Phys Med Rehabil. 2007 Dec 1;86(12):1019-22.

    AbstractIntraspinal drug-delivery therapy has been increasingly used in patients with intractable nonmalignant pain syndromes during the past two decades. Morphine, the only FDA-approved opioid for intrathecal administration, has been the principle agent for such therapy. Although intrathecal morphine infusion can produce profound spinal analgesia, it may also cause some untoward side effects. We describe the first case of persistent hiccup caused by intrathecal morphine infusion therapy.

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