• Massimo Agostoni, Lorella Fanti, Marco Gemma, Nicola Pasculli, Luigi Beretta, and Pier Alberto Testoni.
• Department of Anesthesiology, Vita-Salute University of Milan, IRCCS H. San Raffaele, Milan, Italy. agostoni.massimo@hsr.it
• Gastrointest. Endosc. 2011 Aug 1;74(2):266-75.

BackgroundThe importance of sedation during endoscopy is well established. There is no consensus about the best techniques for sedation, which specialist should perform it, and in which location.ObjectiveTo provide data on the epidemiology of adverse events during sedation for endoscopy.DesignRetrospective analysis of a prospective database.SettingEndoscopy unit of a university hospital.ProceduresA total of 17,999 procedures performed over 8 years.InterventionsSedation for GI endoscopy.Main Outcome MeasurementsWe recorded the following information: sex, age, body mass index, smoking habits, American Society of Anesthesiologists and Mallampati scores, duration of the procedure, type of sedative drug administered, whether the procedure was performed emergently, and endoscopic interventions during the maneuver. Adverse events were defined as occurrences that warranted intervention and were classified as hypotension, desaturation, bradycardia, hypertension, arrhythmia, aspiration, respiratory depression, vomiting, cardiac arrest, respiratory arrest, angina, hypoglycemia, and/or allergic reaction.ResultsDeep sedation with intravenous propofol target controlled infusion pump was the most frequently used means of administering sedation. Adverse events were rare in both the adult (4.5%) and pediatric (2.6%) populations. Six complications occurred in more than 0.1% of adult cases: arterial hypotension, desaturation, bradycardia, arterial hypertension, arrhythmia, and aspiration. Only bradycardia (2.1%) and hypotension (0.44%) occurred in children. Three adult patients (0.017%) died, and no pediatric patients died. Some predictive models for the occurrence of complications are proposed.LimitationsRetrospective analysis, single-center data collection.ConclusionsDeep sedation during endoscopic procedures is safe in both adults and children. Our data may be useful for the future planning of new clinical strategies in this setting.Copyright © 2011 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.

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