• Leukemia research · Oct 2013

    Case Reports

    5q- syndrome and multiple myeloma diagnosed simultaneously and successful treated with lenalidomide.

    • Margarita Ortega, Mar Mallo, Francesc Solé, Carmen Sánchez-Morata, Laura López-Andreoni, Noemí Martínez-Morgado, Mercedes Gironella, David Valcárcel, and Teresa Vallespí.
    • Unidad de Citogenética Hematológica, Hospital Universitario Vall d'Hebrón, Spain.
    • Leuk. Res. 2013 Oct 1;37(10):1248-50.

    AbstractA 72-year-old woman was diagnosed with 5q- myelodysplastic syndrome in the course of an indolent multiple myeloma (MM). Bone marrow (BM) cytogenetics disclosed two unrelated clones: 46,XX,del(5)(q13q33), and [47,X,-X,der(1;21)(q10;q10),-4,-4,+5,del(5)(q13q31),+7,der(7)t(1;7)(p34.2;p22),add(8)(p23),-13,+15,der(16) t(1;16)(q23;q12.2),+19,-21,+mar1,+mar2]. The last complex karyotype belonged to malignant plasma cells. FISH and SKY techniques demonstrated different 5q deletions. EGR1 gene (on 5q31) lost in 5q- syndrome remained in 5q- plasma cells. Biclonal evolution was noted: myeloid 5q- cells added a deletion 13q and plasma cells showed monosomy 13. Patient achieved complete cytogenetic response of 5q- syndrome with low-dose of lenalidomide, and a partial remission of MM with high-dose of lenalidomide/dexamethasone combination.Copyright © 2013 Elsevier Ltd. All rights reserved.

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