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Editorial Comment
A rapidly progressing lymphocyte exhaustion after severe sepsis.
- Guillaume Monneret and Fabienne Venet.
- Crit Care. 2012 Jan 1;16(4):140.
AbstractSeptic syndromes induce immune alterations that have long been considered solely an overwhelming pro-inflammatory response. Increasing evidence now suggests that, after the first pro-inflammatory hours, sepsis is accompanied by the occurrence of a systemic immune failure. Here, novel perspectives regarding sepsis-induced lymphocyte alterations will be discussed in the context of a recently published study investigating overtime evolution of co-inhibitory lymphocyte receptor expressions in patients with severe sepsis.
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