• Human psychopharmacology · Mar 2010

    Multicenter Study Clinical Trial

    Association of BDNF Val66Met polymorphism with both baseline HRQOL scores and improvement in HRQOL scores in Chinese major depressive patients treated with fluoxetine.

    • Yan-Feng Zou, Yu Wang, Ping Liu, Xiao-Liang Feng, Bin-Yan Wang, Tong-Hua Zang, Xin Yu, Jing Wei, Zhong-Chun Liu, Ying Liu, Ming Tao, Hui-Chun Li, Ke-Qing Li, Jian Hu, Ming Li, Ke-Rang Zhang, Dong-Qing Ye, and Xi-Ping Xu.
    • Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China.
    • Hum Psychopharmacol. 2010 Mar 1;25(2):145-52.

    ObjectiveTo explore the association of brain-derived neurotrophic-factor (BDNF) Val66Met polymorphism with both baseline health related quality of life (HRQOL) scores and improvement in HRQOL scores in Chinese major depressive patients treated with fluoxetine.MethodsPatients with major depressive disorder (MDD) took fluoxetine (20 mg/day) for 6 weeks. The HRQOL was measured with the Medical Outcomes Study Short Form-36 (SF-36) at baseline and at 6th week. Patients were genotyped for Val66Met polymorphism of BDNF gene.ResultsThere was a significant association between social function (SF) and BDNF Val66Met polymorphism, and patients with Met/Met genotype had better SF (compared with Val/Val P = 0.004; compared with Val/Met P = 0.005). A significant association was found between improvement in SF and BDNF Val66Met polymorphism, and patients with Met/Met genotype had poorer improvement in SF (compared with Val/Val P = 0.010; compared with Val/Met P = 0.001). Similar association was found between improvement in mental component summary (MCS) and BDNF Val66Met polymorphism, and patients with Met/Met genotype had poorer improvement in MCS (compared with Val/Val P = 0.066; compared with Val/Met P = 0.006).ConclusionsThese results indicate that there may be association between BDNF Val66Met polymorphism and both baseline HRQOL (SF) scores and improvement in HRQOL (SF, MCS) scores in Chinese major depressive patients treated with fluoxetine.Copyright 2010 John Wiley & Sons, Ltd.

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