• Anaesthesia · Apr 2001

    Randomized Controlled Trial Clinical Trial

    Patient-controlled analgesia and postoperative nausea and vomiting: efficacy of a continuous infusion of ondansetron.

    • L A White, M Vanarase, K Brockbank, and R F Barrett.
    • Pain Relief Service, Salisbury District Hospital, Salisbury, Wiltshire SP2 8BJ, UK.
    • Anaesthesia. 2001 Apr 1;56(4):365-9.

    AbstractA continuous infusion of ondansetron was compared with a placebo infusion in 80 patients undergoing major breast reconstructive surgery. All patients received a standard anaesthetic and a bolus dose of ondansetron after induction. They were then randomly allocated to receive an intravenous infusion of ondansetron or a placebo infusion for 24 h in a double-blind fashion. Postoperative analgesia was provided by patient-controlled subcutaneous diamorphine. In the ondansetron group, the severity of nausea, measured by a 10-point verbal rating scale, was reduced (p = 0.01) and fewer patients stated at postoperative interview that nausea and vomiting was a problem (p = 0.01).

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