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J. Invest. Dermatol. · Oct 1978
Comparative StudyThe evaluation of topical anti-inflammatory activity on rat ears subjected to thermal injury.
- R L Bronaugh, R G Roller, and R Cargill.
- J. Invest. Dermatol. 1978 Oct 1;71(4):263-5.
AbstractTopical anti-inflammatory activity of steroidal and non-steroidal agents was assessed on inflammation produced by heat. A burn was produced on the ears of rats and the inflammation was quantitated gravimetrically. Steroidal anti-inflammatory agents were ranked in order of decreasing activity: triamcinolone acetonide, dexamethasone, prednisolone and hydrocortisone acetate. The nonsteroidal agents phenylbutazone and indomethacin were also effective in inhibiting the inflammation. Cholesterol, a steroid devoid of anti-inflammatory activity, was inactive in this test. Hydrocortisone acetate, in particular, appears to be less effective in inhibiting this type of inflammation than inflammation produced by croton oil.
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